Document Detail

The influence of leptin on placental and fetal volume measured by three-dimensional ultrasound in the second trimester.
MedLine Citation:
PMID:  15708113     Owner:  NLM     Status:  MEDLINE    
For a couple of years mechanisms influencing placental and fetal growth and the functioning of leptin, the protein product of the ob/ob gene, have been subjects of intensive research. This study's aim was to investigate whether maternal serum leptin and amniotic fluid leptin have an influence on placental and fetal size measured by three-dimensional ultrasound in the second trimester. To determine this, 40 women with a singleton intrauterine pregnancy at the time of the amniocentesis were included in the study. Placental and fetal volume measurements were obtained and correlated to maternal serum leptin, amniotic fluid leptin, body mass index and gestational age. Multiple regression analysis identified amniotic fluid leptin as an independent negative predictor of placental and fetal volume (r = -2.29, p = 0.032 and r = -0.95, p = 0.011, respectively). In contrast, there was no correlation between maternal serum leptin and placental or fetal volume. The median leptin level in amniotic fluid (9.5 ng/ml) was significantly lower than in maternal blood (18.6 ng/ml). However, there was no significant correlation between maternal serum leptin and amniotic fluid leptin (r = 0.208, n.s.). Body mass index did not reveal any significant influences on placental or fetal volume. The relatively high level of amniotic fluid leptin and its inverse correlation on placental and fetal volume in the second trimester suggest that it possibly plays a role as an anti-placental growth hormone or feedback modulator of substrate supply to the fetus and placenta.
B Woelfer; E Hafner; M Metzenbauer; K Schuchter; K Philipp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  26     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2005 Feb-Mar
Date Detail:
Created Date:  2005-02-14     Completed Date:  2005-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  IM    
Copyright Information:
(c) Elsevier Ltd. All rights reserved.
Ludwig-Boltzmann-Institute of Clinical Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, Donauspital am SMZ-Ost, Langobardenstrasse 122, A-1220 Vienna, Austria.
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MeSH Terms
Amniotic Fluid / metabolism*
Fetal Development
Fetus / anatomy & histology*
Imaging, Three-Dimensional
Leptin / blood*
Middle Aged
Placenta / anatomy & histology*,  metabolism,  ultrasonography
Pregnancy / blood*
Pregnancy Trimester, Second*
Ultrasonography, Prenatal
Reg. No./Substance:

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