Document Detail

The influence of left-ventricular shape on end-diastolic fiber stress and strain.
MedLine Citation:
PMID:  19964050     Owner:  NLM     Status:  MEDLINE    
Passive filling is a major determinant for the pump performance of the left ventricle and is determined by the filling pressure and the ventricular compliance. We quantified the influence of left-ventricular shape on the overall compliance and the distribution of passive fiber stress and strain during the filling period in normal myocardium. Hereto, fiber stress and strain were calculated in a finite element analysis during the inflation of left ventricles of different shape, ranging from an elongated ellipsoid to a sphere, but keeping the initial cavity and wall volume constant. The passive myocardium was described by an incompressible hyperelastic material law with transverse isotropic symmetry along the muscle fiber directions. A realistic transmural gradient in fiber orientation was assumed. While compliance was not altered, the transmural distribution of both passive fiber stress and strain was highly dependent on ventricular shape, where more spherical ventricles exhibited a higher subendocardial gradient in both quantities.
Hon Fai Choi; Jan D'hooge; Frank E Rademakers; Piet Claus
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2887-90     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena
Computer Simulation
Finite Element Analysis
Heart Ventricles / pathology*,  physiopathology*
Models, Biological
Models, Cardiovascular
Models, Theoretical
Myocardial Contraction
Myocardium / pathology
Stress Fibers
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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