Document Detail


The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.).
MedLine Citation:
PMID:  16288926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
American ginseng root (Panax quinquefolius) has a number of purported therapeutic effects, including inhibition of cancer cell proliferation. The ability of environmentally relevant heavy metals to alter ginseng effects on cancer cell growth was the subject of this study. A water extract of American ginseng root was applied alone or in combination with physiologically relevant doses of either lead (Pb) or arsenite to MCF-7 breast cancer cells in vitro and effects on cell proliferation were determined. Ginseng alone produced a significant dose-dependent inhibition of MCF-7 cell proliferation starting at 0.5 mg ml(-1). Treatment of MCF-7 cells with 2.5 microM arsenite significantly decreased MCF-7 cell proliferation (p < 0.01). When cells were treated with arsenite (1.25 or 2.5 microM) in combination with ginseng extract (0.5 mg ml(-1)), there was an apparent synergistic inhibition of cell proliferation. Treatment of MCF-7 breast cancer cells with 50 microM Pb significantly decreased cell proliferation relative to control (p < 0.01), and concomitant ginseng and Pb treatment did not lead to a further decrease. These results suggest that contaminant heavy metals, some of which have been detected in ginseng root extracts or commercial ginseng preparations, may alter the biological activity of ginseng.
Authors:
Rebecca Corbit; Stephen Ebbs; Mandy L King; Laura L Murphy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-11-09
Journal Detail:
Title:  Life sciences     Volume:  78     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1336-40     Citation Subset:  IM    
Affiliation:
Department of Plant Biology, Southern Illinois University Carbondale, Carbondale, IL 62901, USA.
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MeSH Terms
Descriptor/Qualifier:
Arsenites / therapeutic use*
Breast Neoplasms
Cell Division / drug effects*
Cell Line, Tumor
Female
Humans
Lead / pharmacology*
Panax*
Phytotherapy
Plant Extracts / pharmacology*
Plant Roots*
Chemical
Reg. No./Substance:
0/Arsenites; 0/Plant Extracts; 15502-74-6/arsenite; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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