Document Detail

The influence of lactose consumption on the association of oral contraceptive use and ovarian cancer risk.
MedLine Citation:
PMID:  1897499     Owner:  NLM     Status:  MEDLINE    
The authors investigated the joint effects of diet and oral contraceptive use on ovarian cancer risk in 194 white women aged 65 years or less with epithelial ovarian cancer and 193 age- and residence-matched controls in Boston between 1984 and 1987 by using in-person interviews and self-administered food frequency questionnaires. Use of oral contraceptives for 3 months or more was associated with a modest protective effect for ovarian cancer (odds ratio (OR) = 0.7, 95 percent confidence interval (CI) 0.5-1.1). In women who consumed 11 g or less per day of lactose, use of oral contraceptives for 3 months or more was associated with a nonsignificant increased risk (OR = 1.6, 95 percent CI 0.8-3.2). In women who consumed more than 11 g per day of lactose, use of oral contraceptives for 3 months or more was associated with a substantially decreased risk of ovarian cancer (OR = 0.3, 95 percent CI 0.1-0.7). Within this group, the strongest association occurred with more than 4 years of total oral contraceptive use (OR = 0.2, 95 percent CI 0.1-0.6) and in those who had more than 2 years of oral contraceptive use after age 30 years (OR = 0.1, 95 percent CI 0.03-0.4). These results suggest that, with respect to ovarian cancer, lactose users may be the most likely to benefit from oral contraceptive use and that the benefit may be strongest when oral contraceptive use occurs after age 30 years.
B L Harlow; D W Cramer; J Geller; W C Willett; D A Bell; W R Welch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of epidemiology     Volume:  134     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-23     Completed Date:  1991-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  445-53     Citation Subset:  IM; J    
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
Confidence Intervals
Contraceptives, Oral / administration & dosage,  pharmacology*
Lactose / adverse effects,  pharmacology*
Logistic Models
Middle Aged
Odds Ratio
Ovarian Neoplasms / etiology*
Time Factors
Reg. No./Substance:
0/Contraceptives, Oral; 63-42-3/Lactose
Comment In:
Am J Epidemiol. 1991 Sep 1;134(5):454-6   [PMID:  1897500 ]
Am J Epidemiol. 1991 Sep 1;134(5):457-9; discussion 460-1   [PMID:  1897501 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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