Document Detail

The influence of kynurenine, neopterin, and norepinephrine on tubular epithelial cells and alveolar fibroblasts.
MedLine Citation:
PMID:  10721076     Owner:  NLM     Status:  MEDLINE    
We have examined the effect of kynurenine, neopterin and norepinephrine on epithelial cells and fibroblasts: the total DNA synthesis (by adding 3H-thymidine), the mitotic index, the amount of pathological mitosis and apoptosis. We have observed that kynurenine, neopterin and norepinephrine induce pathological mitosis and apoptosis of epithelial cells of kidney. The total DNA synthesis increases by the incubation of the epithelial cells with neopterin and norepinephrine. We have found an increase of pathological mitosis after addition of kynurenine, neopterin and norepinephrine to fibroblast cell culture. The total DNA synthesis is promoted by neopterin and norepinephrine, while kynurenine does not alter it. These data allow us to suggest that kynurenine, neopterin and norepinephrine promote epithelial cell damage leading to cell death through apoptosis, and can therefore be added to the factors, which promote the pathological mitosis of fibroblasts.
A Martinsons; V Rudzite; O Bratslavska; V Saulite
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  467     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Latvia Medical Academy, Riga, Latvia.
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MeSH Terms
Apoptosis / drug effects
Cell Line
Cells, Cultured
Epithelial Cells / cytology,  drug effects*
Kidney Tubules / cytology,  drug effects*
Kynurenine / pharmacology*
Mitosis / drug effects
Mitotic Index / drug effects
Neopterin / pharmacology*
Norepinephrine / pharmacology*
Pulmonary Alveoli / cytology,  drug effects*
Reg. No./Substance:
343-65-7/Kynurenine; 51-41-2/Norepinephrine; 670-65-5/Neopterin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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