| The influence of kynurenine, neopterin, and norepinephrine on tubular epithelial cells and alveolar fibroblasts. | |
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MedLine Citation:
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PMID: 10721076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the effect of kynurenine, neopterin and norepinephrine on epithelial cells and fibroblasts: the total DNA synthesis (by adding 3H-thymidine), the mitotic index, the amount of pathological mitosis and apoptosis. We have observed that kynurenine, neopterin and norepinephrine induce pathological mitosis and apoptosis of epithelial cells of kidney. The total DNA synthesis increases by the incubation of the epithelial cells with neopterin and norepinephrine. We have found an increase of pathological mitosis after addition of kynurenine, neopterin and norepinephrine to fibroblast cell culture. The total DNA synthesis is promoted by neopterin and norepinephrine, while kynurenine does not alter it. These data allow us to suggest that kynurenine, neopterin and norepinephrine promote epithelial cell damage leading to cell death through apoptosis, and can therefore be added to the factors, which promote the pathological mitosis of fibroblasts. |
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Authors:
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A Martinsons; V Rudzite; O Bratslavska; V Saulite |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 467 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-05-09 Completed Date: 2000-05-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 347-52 Citation Subset: IM |
Affiliation:
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Latvia Medical Academy, Riga, Latvia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Cell Line Cells, Cultured Dogs Epithelial Cells / cytology, drug effects* Humans Kidney Tubules / cytology, drug effects* Kynurenine / pharmacology* Mitosis / drug effects Mitotic Index / drug effects Neopterin / pharmacology* Norepinephrine / pharmacology* Pulmonary Alveoli / cytology, drug effects* |
| Chemical | |
Reg. No./Substance:
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343-65-7/Kynurenine; 51-41-2/Norepinephrine; 670-65-5/Neopterin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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