| The influence of intramammary lipopolysaccharide infusion on serum Ca, P, vitamin D, cytokines and cortisol concentrations in lactating sows. | |
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MedLine Citation:
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PMID: 16533325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten multiparous lactating sows were used to investigate whether intramammary infusion of lipopolysaccharides (LPS; Escherichia coli 0111:B4; 2.0 microg/kg of body weight) would affect the circulating concentrations of Ca, P, 25-hydroxyvitamin D (25-OHD), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and cortisol. The sows were randomly allotted to either control group (control) or LPS-treated group with five individuals per group and were infused with either physiological saline solution or LPS solution. The rectal temperature and udder quarter appearance were recorded at 0 (just before infusion), 1, 3, 7, 12 or 24 h after infusion. Blood samples were taken at 0, 1, 3, 7, 12 or 24 h after infusion. Before infusion, the rectal temperatures of all sows were below 39.2 degrees C. At 3 and 7 h after infusion, the sows in the LPS group had a rectal temperature over 39.4 degrees C. At 24 h after infusion, the rectal temperatures returned to pre-infusion levels. Serum Ca and P concentrations in the LPS group decreased (P < 0.05) after LPS infusion compared with the control group at 1 h after infusion. No significant differences (P > 0.05) in the concentrations of 25-OHD were observed between groups control and LPS at any sampling time. Increased (P < 0.01) concentrations of serum TNF-alpha, IL-6 and cortisol were observed in the LPS group compared with the control group at 3 and 7 h after infusion respectively. In conclusion, the elevation of serum concentrations of TNF-alpha, IL-6 and cortisol and the alterations of circulating concentrations of Ca and P following LPS infusion indicate that the immune system has been activated and immune activation may affect macromineral homeostatic regulation, which might have important implications for metabolic health of lactating sows. Lowered serum Ca and P following immune activation also shows a causative mechanism whereby immune activation increases the risk of secondary disorders such as mastitis-metritis-agalactia syndrome. However, immune activation did not affect circulating concentrations of vitamin D metabolites. |
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Authors:
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J F Wang; M Wang; J L Ma; L G Jiao; X Y Zhou; J E Lindberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine Volume: 53 ISSN: 0931-184X ISO Abbreviation: J Vet Med A Physiol Pathol Clin Med Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-14 Completed Date: 2006-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100955112 Medline TA: J Vet Med A Physiol Pathol Clin Med Country: Germany |
Other Details:
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Languages: eng Pagination: 113-8 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine, China Agricultural University, Beijing, China. jiufeng_wang@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Calcium / blood, immunology Cytokines / blood*, immunology Female Hydrocortisone / blood*, immunology Infusions, Intravenous / veterinary Interleukin-6 / blood, immunology Kinetics Lactation Lipopolysaccharides / administration & dosage*, pharmacology Mastitis / blood, veterinary* Phosphorus / blood, immunology Random Allocation Swine Swine Diseases / blood* Tumor Necrosis Factor-alpha / immunology Vitamin D / analogs & derivatives, blood |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-6; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 1406-16-2/Vitamin D; 50-23-7/Hydrocortisone; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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