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The influence of intracoronary injection of bone marrow cells on prothrombotic markers in patients with acute myocardial infarction.
MedLine Citation:
PMID:  22192151     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The effects of intracoronary injection of mononuclear bone marrow cells (mBMC) on haemostasis are not clarified. The aim of the present substudy of the autologous stem cell transplantation in acute myocardial infarction (ASTAMI) trial was to investigate the influence of intracoronary injection of mBMC on selected circulating prothrombotic markers. MATERIALS AND METHODS: One hundred patients with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) on the left descending coronary artery were randomized to receive mBMC (Tx) (median 6days after the STEMI) or to a control group. Fasting blood samples were drawn the day before Tx (day-1, 4-5days after the STEMI), and 1day, 3days, 2-3weeks and 3months after Tx. RESULTS: No significant differences in changes between the groups were observed from day-1 to any later time points in the levels of TF (tissue factor), F1+2 (prothrombin fragment 1+2), D-dimer, ETP (endogenous thrombin potential), PAI-1 (plasminogen activator inhibitor 1) or tissue plasminogen activator. However, TF and F1+2 decreased from day-1 to the subsequent time points in both groups, except from a small increase of TF at 3months in the control group. In both groups, D-dimer and ETP decreased from day-1 to 2-3weeks and 3months, whereas PAI-1 increased to 2-3weeks and 3months. CONCLUSIONS: Intracoronary injection of mBMC did not influence on prothrombotic markers in patients with STEMI. Reduction in several prothrombotic markers from day-1 to 2-3weeks and 3months could be demonstrated in both groups indicating decreased hypercoagulability. This is a substudy of the ASTAMI trial which is registered at www.clinicaltrials.gov, NCT 00199823.
Authors:
Svein Solheim; Ingebjørg Seljeflot; Ketil Lunde; Vibeke Bratseth; Svend Aakhus; Kolbjørn Forfang; Harald Arnesen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-20
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Center for Clinical Heart Research, Oslo University Hospital, Ullevål, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.
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