| The influence of intracellular lactate accumulation upon cell volume and pH in muscle. | |
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MedLine Citation:
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PMID: 17446215 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We would like to thank Dr. Kemp for his letter regarding our recent paper (Usher-Smith et al., 2006). His work is in some respects complimentary to our original paper, in that it attempts to provide an analytic study of some of the processes that we modelled using charge-difference modelling and investigated experimentally. However, we must argue that this analytic approach falls short of capturing the full gamut of interdependent processes that occur during cellular exposure to, or production of, lactic acid. In particular, we will show in this response that whilst the equations derived in Dr. Kemp's letter are generally successful in describing what is physically possible to impose, they are not constrained by what is physiologically reasonable in that they fail to constrain ion fluxes to what is thermodynamically possible given known ion pumps and channels. In addition, some of the more minor points in the letter appear to reflect misunderstandings of the original paper which we hope to clarify here. |
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Authors:
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James Fraser; Juliet Usher-Smith; Christopher Lh Huang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2007-4-19 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-4-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Cambridge. |
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