| The influence of inosine on the size of myocardial ischaemia and myocardial metabolism in the pig. | |
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MedLine Citation:
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PMID: 6889939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In acute experiments on open chest pigs 15 min occlusions of the left anterior descending coronary artery were performed, each occlusion followed by 45 min reperfusion. Myocardial ischaemia was defined by epicardial electrogram recorded from the border of the ischaemic area. Myocardial extraction of lactate and glucose as well as the extraction of FFA were measured before and at the 15th min of occlusion. Inosine (5 mg/kg/min) or 0.9% NaCl infusion was administered i.v. throughout the occlusion period. Inosine significantly diminished the number of ischaemic points and reduced an increase in R-wave voltage induced by coronary occlusion. Myocardial extraction of measured substrates was not significantly influenced by inosine administration. In conclusion, inosine decreases the area of ischaemic injury induced by acute coronary occlusion in the pig. |
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Authors:
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W Czarnecki; K Herbaczynska-Cedro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 2 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 189-97 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Coronary Circulation Coronary Disease / drug therapy, metabolism* Electrocardiography Female Heart / drug effects* Inosine / pharmacology*, therapeutic use Lactates / analysis Male Myocardium / metabolism* Swine |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 58-63-9/Inosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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