| The influence of ingested aluminum upon norepinephrine and dopamine levels in the rat brain. | |
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MedLine Citation:
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PMID: 7198758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical and neuropathological effects of elevated brain aluminum levels have only recently been described. The clinical symptoms, and localization of aluminum in the brain, suggest an altered catecholamine balance. We report the effects of elevated brain aluminum upon the endogenous steady-state levels of norepinephrine and dopamine in the frontal cortex, hippocampus and cerebellum. The neurotoxic effects of ingested aluminum are shown to be dependent upon the dietary intake of copper, zinc, iron, and magnesium. Norepinephrine levels in the cortex and cerebellum decreased in rats fed a low copper diet with aluminum added (0.1%, w/w). Suboptimal iron levels decreased norepinephrine in the cerebellum. The presence of aluminum in diets low in copper or zinc decreased dopamine levels in the cortex. The data are interpreted with respect to the clinical symptomatologies seen in demented, chronic renal dialysis patients with depressed serum copper and zinc levels. |
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Authors:
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G L Wenk; K L Stemmer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurotoxicology Volume: 2 ISSN: 0161-813X ISO Abbreviation: Neurotoxicology Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-03-22 Completed Date: 1982-03-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 347-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum
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toxicity* Animals Brain / drug effects, metabolism* Copper / deficiency Dopamine / metabolism* Male Norepinephrine / metabolism* Rats Rats, Inbred Strains Zinc / deficiency |
| Grant Support | |
ID/Acronym/Agency:
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ES-01566/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 7429-90-5/Aluminum; 7440-50-8/Copper; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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