| The influence of immobilization stress on cardiac protein synthesis. A possible regulatory role for glucocorticoids. | |
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MedLine Citation:
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PMID: 3656271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High serum corticosterone levels and transient depletion of cytosolic glucocorticoid receptor binding capacity were observed in rat cardiac muscle following immobilization stress. To evaluate the effect of this treatment on the protein synthetic capacity, biologically active polyribosomes were used to direct the in vitro synthesis of polypeptides in the rabbit reticulocyte lysate. The results of these experiments indicate that the template activity of several messenger RNAs coding for major myofibrillar proteins was increased. This change in protein synthetic activity was not observed in adrenalectomized animals. Collectively, these results suggest that glucocorticoids are involved in the regulation of cardiac protein biosynthesis. |
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Authors:
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J Gagnon; M A Ho-Kim; G Boissonneault; J Y Dubé; P A Rogers; R R Tremblay |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of receptor research Volume: 7 ISSN: 0197-5110 ISO Abbreviation: J. Recept. Res. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008358 Medline TA: J Recept Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 639-52 Citation Subset: IM; S |
Affiliation:
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Research Unit on Cellular and Molecular Biology of Muscle Laval University Hospital Center, Sainte Foy, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Glucocorticoids / physiology* Male Muscle Proteins / biosynthesis* Myocardium / metabolism* Orchiectomy Polyribosomes / metabolism Protein Biosynthesis Rabbits Rats Rats, Inbred Strains Receptors, Glucocorticoid / physiology Restraint, Physical Reticulocytes / metabolism Stress, Physiological / metabolism* Triamcinolone Acetonide / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Muscle Proteins; 0/Receptors, Glucocorticoid; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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