Document Detail


The influence of image resolution on the positron emission tomographic measurement of caudate glucose consumption.
MedLine Citation:
PMID:  8223768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the influence of image resolution on (a) relative and absolute values of caudate glucose consumption (rCMRGlc) determined by positron emission tomography (PET), and (b) the detection of significant differences in these metabolic values between groups of subjects. For this purpose, raw data of cerebral accumulation of fluorine-18 fluorodeoxyglucose (FDG) obtained in 11 normal subjects and in nine patients with unilateral thalamic infarction were reconstructed using filtered backprojection with four different cut-off frequencies (CFs), yielding images with a transaxial resolution of 5.7, 7.1, 8.9 and 11 mm (full-width at half-maximum; FWHM). Absolute values of caudate rCMRGlc decreased significantly by more than 30% over the range of image resolutions studied. Bilateral ratios of caudate rCMRGlc were insensitive to variations in image resolution. Levels of significance assessing the differences in mean metabolic values between patients and controls were all below 0.01. They were, however, slightly better at image resolutions of 7.1 and 8.9 mm than at a resolution of 5.7 mm. These data indicate (a) that relative values of rCMRGlc are better suited to compare quantitative results from different PET cameras than are absolute values, and (b) that the CF used for the filtered back-projection exerts a small but not negligible influence on levels of significance assessing differences in metabolic values between groups of subjects.
Authors:
T Kuwert; T Sures; H Herzog; P Jansen; K J Langen; M Loken; M Hennerici; L E Feinendegen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  20     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-16     Completed Date:  1993-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  753-8     Citation Subset:  IM    
Affiliation:
Institute of Medicine, Research Centre Jülich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Glucose / metabolism*
Caudate Nucleus / metabolism*,  radionuclide imaging
Deoxyglucose / analogs & derivatives,  diagnostic use
Female
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted*
Infarction / metabolism*,  radionuclide imaging
Male
Middle Aged
Reference Values
Thalamus / blood supply*
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
0/Blood Glucose; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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