| The influence of hormone replacement therapy on skin ageing: a pilot study. | |
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MedLine Citation:
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PMID: 11451620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS: Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, transdermal oestrogen and progesterone (Estraderm TTS 50 and 0.4 mg progesterone vaginal suppository) (n=7); and 3, oral oestrogen and progesterone (2 mg Progynova and 0.4 mg progesterone vaginal suppository) (n=8). One group without therapy was included as a control group (n=3). Treatment was continued for 6 months. Three patients, one from group 2 and two from group 3, discontinued therapy before the study endpoint. The following skin parameters were measured at monthly intervals during treatment: skin surface lipids, epidermal skin hydration, skin elasticity and skin thickness. Concomitant clinical evaluation included a subjective clinical evaluation form, a patient questionnaire and laboratory tests for oestradiol, progesterone and follicle stimulating hormone. RESULTS: Mean levels of epidermal skin moisture, elasticity and skin thickness were improved at the end of treatment based on both subjective and objective evaluation in patients with hormone replacement therapy (HRT). Skin surface lipids were increased during combined HRT, which may reflect stimulatory effects of the progestagen component on sebaceous gland activity, while oestrogen alone has a sebum-suppressive action. In the HRT groups, the questionnaire for climacteric complaints demonstrated significant improvements, while laboratory tests showed increases in oestradiol and progesterone and decreases in FSH. CONCLUSIONS: HRT with the mentioned regimes significantly improved parameters of skin ageing. |
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Authors:
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P G Sator; J B Schmidt; M O Sator; J C Huber; H Hönigsmann |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Maturitas Volume: 39 ISSN: 0378-5122 ISO Abbreviation: Maturitas Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-13 Completed Date: 2001-08-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: Ireland |
Other Details:
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Languages: eng Pagination: 43-55 Citation Subset: IM |
Affiliation:
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Department of Special and Environmental Dermatology, University of Vienna, General Hospital, Währinger Gürtel 18-20, 1090 Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Intravaginal Aged Estrogens / administration & dosage*, blood Female Follicle Stimulating Hormone / blood Hormone Replacement Therapy* Humans Menopause* Middle Aged Pilot Projects Progesterone / administration & dosage*, blood Questionnaires Skin Aging* Skin Physiological Phenomena* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 57-83-0/Progesterone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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