Document Detail

The influence of high temperature on human cells in culture, their sensitivity to viruses and their interferon-producing capacity.
MedLine Citation:
PMID:  2437783     Owner:  NLM     Status:  MEDLINE    
The influence of extremely high temperatures on the course of virus infection in vitro was studied. It has been shown that exposure of human cells (continuous cell line of embryonal skin-muscle tissue, donor blood leukocytes) to 43 degrees C leads to a significant increase in their sensitivity to cytopathic action of the viruses tested. Noteworthy, the reproduction of these viruses under tested conditions did not differ from their reproduction in control cells. A dramatic inhibitory effect of high temperatures on the interferon-producing capacity of cells was observed.
A I Kognovitskaya; A I Bokhonko; T V Mamontova; T G Orlova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  31     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-06-08     Completed Date:  1987-06-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cytopathogenic Effect, Viral
Encephalomyocarditis virus / growth & development*
Hot Temperature
Influenza A virus / growth & development*
Interferons / biosynthesis*
Newcastle disease virus / immunology*
Vesicular stomatitis Indiana virus / growth & development*
Reg. No./Substance:

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