| The influence of hemorrhage on liver microcirculation of the cirrhotic rat. | |
| | |
MedLine Citation:
|
PMID: 8262719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bleeding from esophageal varices is highly lethal in cirrhotics, the main cause of death being liver failure. Because adequate hepatic perfusion is a prerequest for the maintenance of liver function, the present study was designed to evaluate the influence of hemorrhagic shock on liver microcirculation in rats with portal hypertension due to cirrhosis of the liver induced by CCl4. In 16 cirrhotic rats and an equal number of controls, hepatic microcirculation was continuously assessed--by means of laser-Doppler flowmetry, through a self-adhesive probe attached to the liver surface, before and during a 15 min period of arterial hypotension (40 mmHg) induced by blood withdrawal. Our findings revealed that immediately following hemorrhage there is a statistically significant reduction of microcirculation in cirrhotics versus controls. The results of this study assist in the better understanding of the hemodynamic conditions which prevail in the cirrhotic liver during the first minutes of hemorrhage. |
| | |
Authors:
|
E Eleftheriadis; K Kotzampassi; A Herodotou; H Aletras |
Related Documents
:
|
10218129 - Effects of ligustrazine on hepatic oxygenation in isolated perfused rat liver. 7439339 - Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid. 1649989 - Oxygen-dependent erythropoietin production by the isolated perfused rat kidney. 7077129 - Hepatic clearance and biliary secretion of protoporphyrin in the isolated, in situ-perf... 702339 - Kinetics of metabolite formation and elimination in the perfused rat liver preparation:... 10493939 - Zonation of gluconeogenesis, ketogenesis and intracellular ph in livers from normal and... 21630039 - Tetraethylammonium enhances the rectal and colonic motility in rats and human in vitro. 7100279 - Early life undernutrition and operant responding in the rat: the effect of the reinforc... 1912299 - Species specificity in the chemical mechanisms of organophosphorus anticholinesterase a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation Volume: 13 ISSN: 0167-6865 ISO Abbreviation: Int J Microcirc Clin Exp Publication Date: 1993 Aug |
Date Detail:
|
Created Date: 1994-01-27 Completed Date: 1994-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8400122 Medline TA: Int J Microcirc Clin Exp Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 27-34 Citation Subset: IM |
Affiliation:
|
Department of Surgery, University of Thessaloniki, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Animals Hemorrhage / physiopathology* Laser-Doppler Flowmetry Liver / blood supply* Liver Cirrhosis, Experimental / physiopathology* Male Microcirculation / physiology Rats Rats, Wistar |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of leukocyte adhesion and microvascular permeability on capillary perfusion during ischemia-r...
Next Document: Routine anaerobic bacterial culture and systemic antibiotic usage in the treatment of adult periodon...