| The influence of heating on the anticancer properties of garlic. | |
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MedLine Citation:
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PMID: 11238815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allyl sulfur compounds are the major active constituents found in crushed garlic. Research has revealed that garlic and its lipid- or water-soluble components have many pharmacologic properties; however, studies also demonstrate that heating has a negative influence on these beneficial effects. We recently conducted several studies to investigate the influence of microwave or oven heating on the anticarcinogenesis property of garlic. Our studies showed that as little as 60 s of microwave heating or 45 min of oven heating can block garlic's ability to inhibit in vivo binding of mammary carcinogen [7,12-dimethylbenzene(a)anthracene (DMBA)] metabolites to rat mammary epithelial cell DNA. Allowing crushed garlic to "stand" for 10 min before microwave heating for 60 s prevented the total loss of anticarcinogenic activity. Our studies demonstrated that this blocking of the ability of garlic was consistent with inactivation of alliinase. These studies suggest that heating destroyed garlic's active allyl sulfur compound formation, which may relate to its anticancer properties. |
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Authors:
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K Song; J A Milner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of nutrition Volume: 131 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-04-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1054S-7S Citation Subset: IM |
Affiliation:
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Graduate Program in Nutrition and Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticarcinogenic Agents / metabolism* Benz(a)Anthracenes / metabolism* Carbon-Sulfur Lyases / antagonists & inhibitors* Carcinogens DNA Adducts / metabolism Enzyme Inhibitors Female Garlic / metabolism* Hot Temperature / adverse effects* Mammary Glands, Animal / drug effects, enzymology* Microwaves Plants, Medicinal* Rats |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Benz(a)Anthracenes; 0/Carcinogens; 0/DNA Adducts; 0/Enzyme Inhibitors; 2564-65-0/7,12-dihydroxymethylbenz(a)anthracene; EC 4.4.-/Carbon-Sulfur Lyases; EC 4.4.1.4/alliin lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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