Document Detail


The influence of glycoprotein hormones selected properties of selected properties of glycoprotein hormones on their absorption after intranasal administration in foxes.
MedLine Citation:
PMID:  10961023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption of glycoprotein hormones, i.e. folitropin and lutropin, whose approximate molecular weight is 30,000 D, were estimated for the intranasal administration. The maximal hormone concentrations were observed 30 minutes after their administration. The maximal concentration of folitropin was 32% higher than the maximal concentration of lutropin. Bioavailability level for foliotropin was 138.58% compared to lutropin bioavailability level, which was considered the pattern bioavailability level (100%) in our experiments. It was established that the absorption of hormones from nasal mucous membrane depended not only on their molecular mass but also on the isoelectric point, content of carbohydrates and sialic acids. Hormonal substances of acid character, containing a greater content of carbohydrates and sialic acids (as in the case of folitropin) were absorbed from the nasal mucosa more rapidly.
Authors:
F Ryszka; B Dolinska; A Suszka-Switek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  139     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-09-18     Completed Date:  2000-09-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  129-31     Citation Subset:  IM    
Affiliation:
Department of Applied Pharmacy and Drug Technology Silesian Medical Academy, Kasztanowa, Poland.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Intranasal
Animals
Area Under Curve
Female
Follicle Stimulating Hormone / administration & dosage,  chemistry,  pharmacokinetics*
Foxes / metabolism*
Luteinizing Hormone / administration & dosage,  chemistry,  pharmacokinetics*
Chemical
Reg. No./Substance:
9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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