| The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat. | |
| | |
MedLine Citation:
|
PMID: 20404036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The insulin-like growth factor (IGF) axis, a key regulator of embryonic growth and development, is exquisitely sensitive to the nutrient status of the animal. In addition to macronutrient deficiencies, zinc deficiency can impact the IGF axis. Gestational zinc deficiency is teratogenic, resulting in intrauterine growth retardation and structural abnormalities. The aim of this study was to investigate the effects of gestational zinc deficiency on the fetal IGF axis in a rat model. From gestation day (GD) 0.5, dams consumed zinc-deficient (ZD, 0.3 mg zinc/kg) or control (25 mg zinc/kg) diet ad libitum, while a third group of dams consumed the control diet in amounts equivalent to the food intake of the ZD dams (Paired group). On GD 19.5 fetal tissue, blood and amniotic fluid were collected. Fetal growth was significantly reduced by zinc deficiency compared with the Paired and Control groups. Fetuses from the Paired group were smaller compared with the Control, but only ZD fetuses had structural malformations. Amniotic fluid IGF-1 concentrations were significantly lower in the Paired group than in the ZD and Control groups. Plasma of ZD fetuses contained lower levels of IGF binding protein-1 when compared with fetuses in the Paired and Control groups. Fetal liver IGF-1 mRNA levels were lower in the ZD fetuses than in the Paired and Control fetuses. These observations suggest that differences in the fetal IGF axis between ZD and Paired groups contribute to the poor pregnancy outcome and enhanced fetal growth retardation observed with zinc deficiency. |
| | |
Authors:
|
Lynn A Hanna; Michael S Clegg; Robert G Ellis-Hutchings; Brad J Niles; Carl L Keen |
Related Documents
:
|
1307736 - Understanding the different phases of fetal growth. 18195356 - Sexual maturity in growing dinosaurs does not fit reptilian growth models. 22336906 - Maternal serum vitamin d levels at 11-13 weeks of gestation in preeclampsia. 15277896 - Pathophysiology of fetal growth restriction: implications for diagnosis and surveillance. 10211126 - Thermomechanical analysis of collagen crosslinking in the developing lamb pericardium. 20414166 - On categorizing gestational, birth, and neonatal complications following late pregnancy... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-04-20 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
|
Languages: eng Pagination: 206-14 Citation Subset: IM |
Affiliation:
|
Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA. lhanna@csus.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniotic Fluid
/
metabolism Animals Female Fetal Blood / metabolism Fetus / metabolism* Insulin-Like Growth Factor Binding Protein 1 / blood, genetics, metabolism Insulin-Like Growth Factor Binding Protein 2 / blood, genetics, metabolism Insulin-Like Growth Factor I / genetics, metabolism Insulin-Like Growth Factor II / genetics Liver / metabolism Male Placenta / metabolism Pregnancy Pregnancy Complications / metabolism* RNA, Messenger / genetics, metabolism Rats Rats, Sprague-Dawley Somatomedins / metabolism* Zinc / deficiency* |
| Grant Support | |
ID/Acronym/Agency:
|
DK007059/DK/NIDDK NIH HHS; DK007355/DK/NIDDK NIH HHS; HD01743/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/RNA, Messenger; 0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevation of tumor necrosis factor-alpha induces the overproduction of postprandial intestinal apoli...
Next Document: Thyroid hormone concentrations in systemic circulation and ovarian follicular fluid of cows.