Document Detail


The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde.
MedLine Citation:
PMID:  23355119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The International Agency for Research on Cancer classified formaldehyde as carcinogenic to humans because there is "sufficient epidemiological evidence that it causes nasopharyngeal cancer in humans". Genes involved in DNA repair and maintenance of genome integrity are critically involved in protecting against mutations that lead to cancer and/or inherited genetic disease. Association studies have recently provided evidence for a link between DNA repair polymorphisms and micronucleus (MN) induction. We used the cytokinesis-block micronucleus (CBMN assay) in peripheral lymphocytes and MN test in buccal cells to investigate the effects of XRCC3 Thr241Met, ADH5 Val309Ile, and Asp353Glu polymorphisms on the frequency of genotoxicity biomarkers in individuals occupationally exposed to formaldehyde (n = 54) and unexposed workers (n = 82). XRCC3 participates in DNA double-strand break/recombination repair, while ADH5 is an important component of cellular metabolism for the elimination of formaldehyde. Exposed workers had significantly higher frequencies (P < 0.01) than controls for all genotoxicity biomarkers evaluated in this study. Moreover, there were significant associations between XRCC3 genotypes and nuclear buds, namely XRCC3 Met/Met (OR = 3.975, CI 1.053-14.998, P = 0.042) and XRCC3 Thr/Met (OR = 5.632, CI 1.673-18.961, P = 0.005) in comparison with XRCC3 Thr/Thr. ADH5 polymorphisms did not show significant effects. This study highlights the importance of integrating genotoxicity biomarkers and genetic polymorphisms in human biomonitoring studies.
Authors:
Carina Ladeira; Susana Viegas; Elisabete Carolino; Manuel C Gomes; Miguel Brito
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Publication Detail:
Type:  Journal Article     Date:  2013-01-28
Journal Detail:
Title:  Environmental and molecular mutagenesis     Volume:  54     ISSN:  1098-2280     ISO Abbreviation:  Environ. Mol. Mutagen.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-05-06     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8800109     Medline TA:  Environ Mol Mutagen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Escola Superior de Tecnologia da Saúde de Lisboa - Instituto Politécnico de Lisboa, Portugal. carina.ladeira@estesl.ipl.pt
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldehyde Oxidoreductases / genetics*
Biological Markers / analysis
DNA Repair / genetics
DNA-Binding Proteins / genetics*
Environmental Monitoring
Female
Formaldehyde / toxicity*
Gene Frequency
Genetic Association Studies
Genotype
Humans
Logistic Models
Lymphocytes / cytology,  metabolism
Male
Micronuclei, Chromosome-Defective / chemically induced,  statistics & numerical data
Micronucleus Tests
Mouth Mucosa / cytology,  metabolism
Mutagens / toxicity*
Occupational Exposure / analysis*,  statistics & numerical data
Polymorphism, Genetic*
Workplace / standards
Chemical
Reg. No./Substance:
0/Biological Markers; 0/DNA-Binding Proteins; 0/Mutagens; 0/X-ray repair cross complementing protein 3; 50-00-0/Formaldehyde; EC 1.2.-/Aldehyde Oxidoreductases; EC 1.2.1.46/formaldehyde dehydrogenase, glutathione-independent

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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