Document Detail

The influence of genetic factors on brain plasticity and recovery after neural injury.
MedLine Citation:
PMID:  23044515     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The fields of clinical genetics and pharmacogenetics are rapidly expanding. Genetic factors have numerous associations with injury and with treatment effects in the setting of neural plasticity and recovery.
RECENT FINDINGS: Evidence is reviewed that established genetic variants, as well as some more recently described variants, are related to outcome after neural injury and in some cases are useful for predicting clinical course. In many cases, the interaction of genetics with clinical factors such as experience and therapy may be important. As an extension of this, genetic factors have been associated with differential response to a number of forms of therapy, including pharmacological, brain stimulation, psychotherapy, and meditation. Genetic variation might also have a significant effect on plasticity and recovery through key covariates such as depression or stress. A key point is that genetic associations might be most accurately identified when studied in relation to distinct forms of a disorder rather than in relation to broad clinical syndromes.
SUMMARY: Understanding genetic variation gives clinicians a biological signal that could be used to predict who is most likely to recover from neural injury, to choose the optimal treatment for a patient, or to supplement rehabilitation therapy.
Kristin M Pearson-Fuhrhop; Erin Burke; Steven C Cramer
Related Documents :
9860305 - Molecular characterization of phenylketonuria in japanese patients.
25049475 - Genotype and allelic frequencies of a newly identified mutation causing blindness in jo...
14983655 - Molecular identification of combined homozygous and compound heterozygous mutations in ...
20082265 - Variations in genotype-phenotype correlations in phenylketonuria patients.
18708425 - A pcsk9 variant and familial combined hyperlipidaemia.
11756195 - Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  25     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-05-03     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  682-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Nervous System Diseases* / genetics,  rehabilitation
Neuronal Plasticity / genetics*
Recovery of Function / genetics*
Stroke / genetics,  rehabilitation
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polychlorinated biphenyls in prospectively collected serum and Parkinson's disease risk.
Next Document:  Genetics of hearing and deafness.