Document Detail

The influence of gastrointestinal parasitism on fecal elimination of doramectin, in lambs.
MedLine Citation:
PMID:  20828822     Owner:  NLM     Status:  MEDLINE    
A study was done to investigate the effect of parasitism on patterns of doramectin (DRM) fecal elimination in lambs. Fourteen Suffolk Down parasitized lambs (26.9 ± 1.5 kg body weight: bw) were purposely selected for the study. Seven pairs of lambs were allocated into two experimental groups. Group I (non-parasitized) was pre-treated with 3 repeated administrations of 5mg/kg bw of fenbendazole to maintain a non-parasitized condition. In Group II (parasitized), the lambs did not receive any anthelmintic treatment. After 85 d of the pre-treatment period, both groups were treated with a subcutaneous injection of 200 μg/kg bw of DRM. Fecal samples were collected at different times between -85 d before and 60 d after the DRM treatment, for both parasitological and chromatographic analysis. Samples were analyzed by high-performance liquid chromatography (HPLC) with fluorescence detection. Data of DRM concentrations were expressed as wet weight. A non-linear pharmacokinetic analysis was performed and results were compared using the Mann Whitney test. Fecal maximum concentrations (C(max)) of DRM were 1.37 ± 0.19 μg/g (parasitized group) and 0.86 ± 0.15 μg/g (non-parasitized group) observed at the time of the maximum concentration (T(max)) of 2.1 ± 0.4 and 3.1 ± 0.3d, respectively. Differences in C(max) values were significant (P<0.05). The accumulated elimination of DRM in feces, expressed as the percentage of DRM total dose, was 67.1% in the parasitized group, whereas in the non-parasitized group it was 56.5%. Our results showed that gastrointestinal parasitic diseases can modify the patterns of DRM fecal elimination, when the drug is administered by subcutaneous route in lambs.
Rubén Pérez; Cristina Palma; Ignacio Cabezas; Luis Rubilar; Margarita Arboix
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  73     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2017-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Laboratorio de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Concepción, Campus Chillán, Chile. rubperez@udec.c
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MeSH Terms
Anthelmintics / administration & dosage,  pharmacokinetics,  therapeutic use*
Chromatography, High Pressure Liquid
Disease Models, Animal*
Dose-Response Relationship, Drug
Feces / parasitology*
Injections, Subcutaneous
Intestinal Diseases, Parasitic / drug therapy,  parasitology,  veterinary*
Ivermectin / administration & dosage,  analogs & derivatives,  pharmacokinetics,  therapeutic use*
Parasite Egg Count
Sheep Diseases / drug therapy*,  parasitology
Time Factors
Reg. No./Substance:
0/Anthelmintics; 117704-25-3/doramectin; 70288-86-7/Ivermectin

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