Document Detail


The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice.
MedLine Citation:
PMID:  11982858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A primary infection with Plasmodium chabaudi chabaudi (AS) is characterized by an expansion of gammadelta cells after the acute phase of infection in mice. This is particularly marked during chronic infections in B cell-deficient mice. Infections in gammadelta T cell-deficient mice suggest that, although these cells play some role in the control of parasitaemia and can produce interferon-gamma, they do not appear to be involved in the development of hypoglycaemia, loss of weight and temperature during a P. c. chabaudi infection. However, gammadelta T cells do influence the nature of the CD4+ T cell response during infection since, in their absence, Th2-like responses, such as interleukin (IL)-4 production and help for malaria-specific antibody responses, are more pronounced. This alteration in CD4+ T cells is reflected in a more rapid and greater immunoglobulin (Ig)G1 and IgG3 antibody response to the parasite. The large gammadelta T cell expansion normally observed in infected B cell-deficient mice did not take place in the absence of IL-2, and double-knockout mice lacking both B cells and functional IL-2 were highly susceptible to lethal infection with P. c. chabaudi. The majority of the single IL-2 knockout mice, in contrast, were able to control and clear a primary infection, suggesting that for the CD4+ T cell and antibody response, IL-2 could be replaced by other cytokines.
Authors:
Elsa Seixas; Luis Fonseca; Jean Langhorne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  24     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-01     Completed Date:  2002-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-40     Citation Subset:  IM    
Affiliation:
Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Protozoan / biosynthesis*
CD4-Positive T-Lymphocytes / immunology
Female
Immunoglobulin G / biosynthesis
Interleukin-2 / biosynthesis,  genetics
Malaria / immunology*,  parasitology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mutation
Parasitemia / immunology,  parasitology
Plasmodium chabaudi / immunology*
Receptors, Antigen, T-Cell, gamma-delta / genetics,  physiology*
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Immunoglobulin G; 0/Interleukin-2; 0/Receptors, Antigen, T-Cell, gamma-delta

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