| The influence of fundamental traits on mechanisms controlling appendage regeneration. | |
| | |
MedLine Citation:
|
PMID: 21929739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
One of the most compelling questions in evolutionary biology is why some animals can regenerate injured structures while others cannot. Appendage regeneration appears to be common when viewed across the metazoan phylogeny, yet this ability has been lost in many taxa to varying degrees. Within species, the capacity for regeneration also can vary ontogenetically among individuals. Here we argue that appendage regeneration along the secondary body axis may be constrained by fundamental traits such as body size, aging, life stage, and growth pattern. Studies of the molecular mechanisms affecting regeneration have been conducted primarily with small organisms at early life stages. Such investigations disregard the dramatic shifts in morphology and physiology that organisms undergo as they age, grow, and mature. To help explain interspecific and intraspecific constraints on regeneration, we link particular fundamental traits to specific molecular mechanisms that control regeneration. We present a new synthesis for how these fundamental traits may affect the molecular mechanisms of regeneration at the tissue, cellular, and genomic levels of biological organization. Future studies that explore regeneration in organisms across a broad phylogenetic scale, and within an ontogenetic framework, will help elucidate the proximate mechanisms that modulate regeneration and may reveal new biomedical applications for use in regenerative medicine. |
| | |
Authors:
|
Ashley W Seifert; James R Monaghan; Matthew D Smith; Bret Pasch; Adrian C Stier; François Michonneau; Malcolm Maden |
Related Documents
:
|
7186719 - Tuberculosis infection and disease in zambia. a tuberculin survey in three areas in zam... 9524399 - Measles in victoria 1992 to 1996: the importance of laboratory confirmation. 9441079 - Does pulmonary tuberculosis change with ageing? 2347959 - Histopathologic characteristics of dysplastic nevi. limited association of conventional... 16970639 - Prevalence of tuberculous infection and active tuberculosis in old age homes in hong kong. 1479599 - A genetic study of type 2 neurofibromatosis in the united kingdom. ii. guidelines for g... 18092439 - Assessment of pulmonary function in local healthy nepalese men of dharan and it's anthr... 9347099 - Utility of biological markers during outpatient treatment of alcohol-dependent subjects... 23244349 - Changes in the stature, body mass and age of english professional rugby players: a 10-y... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-19 |
Journal Detail:
|
Title: Biological reviews of the Cambridge Philosophical Society Volume: - ISSN: 1469-185X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0414576 Medline TA: Biol Rev Camb Philos Soc Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Biological Reviews © 2011 Cambridge Philosophical Society. |
Affiliation:
|
Nexus Biology Group, University of Florida, 223 Bartram Hall, P.O. Box 118525, Gainesville, FL 32611, USA Department of Biology, University of Florida, 223 Bartram Hall, P.O. Box 118525, Gainesville, FL 32611, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's diseas...
Next Document: Thyrocervical Trunk Pseudoaneurysm Following Central Venous Catheterization.