| The influence of fetal loss on the presence of fetal cell microchimerism: a systematic review. | |
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MedLine Citation:
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PMID: 14613289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Fetal cells enter the maternal circulation during most pregnancies. Their persistence for years occurs in only some women and has been associated with several autoimmune diseases such as systemic sclerosis. The objective of this study was to determine whether pregnancy history influences the persistence of fetal microchimeric cells. METHODS: We reviewed all reports of studies on fetal cell microchimerism, defined as male DNA in maternal tissue, that describe individual pregnancy histories, disease diagnoses, and microchimerism status. The total numbers of pregnancies, births, and sons, the history of fetal loss (spontaneous abortion and elective termination), and the presence of a maternal autoimmune disease were tested as factors potentially associated with persistent microchimerism. RESULTS: One hundred twenty-four subjects from 11 studies met the inclusion criteria. Only fetal loss was significantly associated with the presence of microchimerism (odds ratio 2.4, 95% confidence interval 1.2-6.0). CONCLUSION: These results suggest that fetomaternal cell trafficking following fetal loss may be important for the engraftment of microchimeric cells in maternal tissue. This may be due to an increased amount of fetomaternal transfusion or to transfer of a cell type that is more likely to engraft. We recommend that investigators in future studies on microchimerism report detailed pregnancy information, since these data are critical for the understanding of factors that influence the development of fetal cell microchimerism. |
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Authors:
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Kiarash Khosrotehrani; Kirby L Johnson; Joseph Lau; Alain Dupuy; Dong Hyun Cha; Diana W Bianchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 48 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-12 Completed Date: 2003-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 3237-41 Citation Subset: AIM; IM |
Affiliation:
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Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoimmune Diseases / etiology*, immunology Chimera* / immunology Chromosomes, Human, Y DNA / blood Female Fetal Blood / cytology, immunology Fetal Death / complications* Graft vs Host Disease / immunology Humans In Situ Hybridization, Fluorescence Male Maternal-Fetal Exchange* / immunology Polymerase Chain Reaction Pregnancy |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Arthritis Rheum. 2004 Sep;50(9):3058-9; author reply 3059
[PMID:
15457487
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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