| The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias). | |
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MedLine Citation:
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PMID: 19782147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dogfish sharks are opportunistic predators, eating large meals at irregular intervals. Here we present a synthesis of data from several previous studies on responses in plasma metabolites after natural feeding and during prolonged fasting (up to 56days), together with new data on changes in plasma concentrations of amino acids and non-esterified fatty acids. Post-prandial and long-term fasting responses were compared to control sharks fasted for 7days, a typical inter-meal interval. A feeding frenzy was created in which dogfish were allowed to feed naturally on dead teleosts at two consumed ration levels, 2.6% and 5.5% of body weight. Most responses were more pronounced at the higher ration level. These included increases in urea and TMAO concentrations at 20h, followed by stability through to 56days of fasting. Ammonia levels were low and exhibited little short-term response to feeding, but declined to very low values during the extended fast. Glucose and beta-hydroxybutyrate both fell after feeding, the latter to a greater and more prolonged extent (up to 60h), whereas acetoacetate did not change. During prolonged fasting, glucose concentrations were well regulated, but beta-hydroxybutyrate increased to 2-3-fold control levels. Total plasma amino acid concentrations increased in a biphasic fashion, with peaks at 6-20h, and 48-60h after the meal, followed by homeostasis during the extended fast. Essential and non-essential amino acids generally followed this same pattern, though some exhibited different trends after feeding: taurine, beta-alanine, and glycine (decreases or stability), alanine and glutamine (modest prolonged increases), and threonine, serine, asparagine, and valine (much larger short-term increases). Plasma non-esterified fatty acid concentrations declined markedly through 48h after the 2.6% meal. These data are interpreted in light of companion studies showing elevations in aerobic metabolic rate, urea production, rectal gland function, metabolic base excretion, and activation of ornithine-urea cycle and aerobic enzymes after the meal, and muscle N-depletion but maintenance of osmolality and urea production during long-term fasting. |
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Authors:
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Chris M Wood; Patrick J Walsh; Makiko Kajimura; Grant B McClelland; Shit F Chew |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-09-24 |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 155 ISSN: 1531-4332 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 435-44 Citation Subset: IM |
Affiliation:
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Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada. woodcm@mcmaster.ca <woodcm@mcmaster.ca> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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blood Amino Acids / blood* Ammonia / blood Animals Blood Glucose / metabolism Dogfish / blood, metabolism* Eating* Energy Metabolism* Fasting / blood* Fatty Acids, Nonesterified / blood* Feeding Behavior* Methylamines / blood Osmolar Concentration Postprandial Period Predatory Behavior* Time Factors Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Methylamines; 1184-78-7/trimethyloxamine; 300-85-6/3-Hydroxybutyric Acid; 57-13-6/Urea; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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