| The influence of fatty acids on model cholesterol/phospholipid membranes. | |
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MedLine Citation:
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PMID: 17651712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work was to verify the influence of the saturated (SFA) (stearic acid) and the unsaturated (UFA) (oleic and alpha-linolenic) fatty acids on model cholesterol/phospholipid membranes. The experiments were based on the Langmuir monolayer technique. Cholesterol and phospholipid were mixed in the molar ratio that corresponds to the proportion of these lipids in the majority of natural human membranes. Into the binary cholesterol/phospholipid monolayers, various amounts of fatty acids were incorporated. Our investigations were based on the analysis of the interactions between molecules in ternary (cholesterol/phospholipids/fatty acid) mixtures, however, also binary (cholesterol/fatty acid and phospholipids/fatty acid) mixed system were examined. It was concluded that the influence of the fatty acids on model cholesterol/phospholipid membrane is closely connected with the shape of the fatty acid molecule, resulting from the saturation degree of the hydrocarbon chain. It was found that the saturated fatty acid makes the model membrane more rigid, while the presence of unsaturated fatty acid increases its fluidity. The increasing amount of stearic acid gradually destabilizes model membrane, however, this effect is the weakest at low content of SFA in the mixed monolayer. Unsaturated fatty acids in a small proportion make the membrane thermodynamically more stable, while higher content of UFA decreases membrane stability. This explains low proportion of the free fatty acids to other lipids in natural membrane. |
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Authors:
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Katarzyna Hac-Wydro; Paweł Wydro |
Publication Detail:
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Type: Journal Article Date: 2007-06-21 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 150 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-15 Completed Date: 2007-12-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 66-81 Citation Subset: IM |
Affiliation:
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Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane
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chemistry* Cholesterol / metabolism* Fatty Acids / pharmacology* Humans Membrane Fluidity / drug effects Models, Biological Phospholipids / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phospholipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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