Document Detail

The influence of exercise on albumin excretion rate in borderline hypertensives and in offspring of hypertensive parents.
MedLine Citation:
PMID:  9140799     Owner:  NLM     Status:  MEDLINE    
We investigated exercise induced urinary albumin excretion rate (UAE)(ex-UAE) in patients with borderline hypertension (BH) compared to normotensives with positive-PFH and negative-NFH family history of hypertension. The study population consisted of 20 young, non-obese males with BH defined according to WHO criteria and confirmed by 24 h ambulatory blood pressure (ABP) and 40 healthy matched normotensives (PFH = 20 and NFH = 20). Twenty-four hour UAE was assessed by day and night time urine collection. BH and normotensive subjects performed a 20 min ergometric graded exercise test. The relationship between 24 h UAE, 24 h ABP and 2-D-echocardiographic left ventricular mass index (LVMI) were examined. The three groups did not differ in 24 h UAE. Exercise induced a significant increase in UAE only in BH. Exercise induced UAE was greater in BH compared to normotensives: BH = 54.3(21-125), PFH = 37.6(13-62), NFH = 9.7(0-35)micrograms/min, data expressed as median (I quartile-III quartile). Pooled data from all three groups showed a positive correlation between ex-UAE and systolic BP (SBP) during night time (by multiple regression analysis). In conclusion, BH without other known cardiovascular risk factors, moderate dynamic exercise induced an excessive increase in UAE.
Z Purzycki; B Wyrzykowski; K Gockowski; M M Winnicki; M Kazmirowicz; B Krupa-Wojciechowska; J R Sowers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  11     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Cardiac Diagnostic Center, Medical Academy, Gdansk, Poland.
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MeSH Terms
Albuminuria / genetics,  physiopathology*
Blood Pressure
Exercise Test
Hypertension / genetics,  physiopathology*,  urine
Risk Factors

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