Document Detail

The influence of exercise and aging on immune function.
MedLine Citation:
PMID:  8007806     Owner:  NLM     Status:  MEDLINE    
Immune function declines significantly with advancing age. While many components of the immune system are adversely affected, T cell-dependent functions are most dramatically compromised. This is most likely a result of involution of the thymus gland known to occur with age. Defects in T cell proliferative capacity/responsiveness, interleukin-2 production and receptor expression, signal transduction, and cytotoxicity are frequently cited problems associated with immunosenescence. The stress imposed by a single bout of exercise elicits a number of cardiovascular, thermoregulatory, and neuroendocrine responses that can directly influence many variables associated with the immune system. Consequently, during exercise, as well as into the subsequent recovery period, immune function can be significantly altered. Further, recent work has shown that as a result of endurance training adaptations in both baseline and exercising immune function can occur. However, extremely little is known regarding the interaction between exercise, aging and the immune system. Given that a number of age-related changes occur in many systems (e.g., neuroendocrine) known to alter immune function both at rest and during exercise, it would be of value to learn the extent to which both acute and chronic exercise influence immune function in the elderly.
R S Mazzeo
Related Documents :
9212346 - Effect of endurance exercise on the tissue 8-hydroxy-deoxyguanosine content in dogs.
19208046 - Exercise is associated with elevated proinflammatory cytokines in human milk.
1447096 - Immune responses and increased training of the elite athlete.
20839496 - The open window of susceptibility to infection after acute exercise in healthy young ma...
1883666 - Post-prandial worsening of angina: all due to changes in cardiac output?
2369906 - Changes in breathing pattern at loads near perceptual threshold at different work levels.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  26     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-07-21     Completed Date:  1994-07-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-92     Citation Subset:  IM; S    
Department of Kinesiology, University of Colorado, Boulder 80309.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / immunology*
Exercise / physiology*
Immunity, Cellular / physiology*
Lymphocyte Activation / immunology
Neurosecretory Systems / immunology
Physical Endurance / immunology
Physical Exertion / physiology*
T-Lymphocytes / immunology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of age on skeletal muscle glucose transport and glycogen metabolism.
Next Document:  Skeletal muscle fiber type, resistance training, and strength-related performance.