| The influence of ethanol on pharmacokinetic parameters of procainamide in rabbits. | |
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MedLine Citation:
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PMID: 3413215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of ethanol on procainamide pharmacokinetics was investigated in rabbits. Procainamide was injected iv in a dose of 13 mg.kg-1 together with ethanol in doses of 0.1, 0.5 or 1.0 g.kg-1.h-1. In another experiment procainamide was given in a dose of 40 mg.kg-1 together with ethanol in a dose of 1.0 g.kg-1 p.o. The third group of rabbits received procainamide in the form of 1 tablet 0.25 g together with ethanol in a dose of 1.0 g.kg-1 p.o. Ethanol shortened biological half-life of procainamide elimination, increased the value of the rate constant of elimination and procainamide clearance. Concomitant oral administration of ethanol and procainamide decreased the peak plasma concentration and decreased the area under the drug level curve. |
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Authors:
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D Orszulak-Michalak; P Polakowski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 43 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-10-03 Completed Date: 1988-10-03 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 260-1 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, Medical Academy Lódź, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Drug Interactions Ethanol / pharmacology* Injections, Intravenous Procainamide / administration & dosage, pharmacokinetics* Rabbits Tablets |
| Chemical | |
Reg. No./Substance:
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0/Tablets; 51-06-9/Procainamide; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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