| The influence of estradiol and diet on small intestinal glucose transport in ovariectomized rats. | |
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MedLine Citation:
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PMID: 14988514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although gender differences exist for intestinal absorption of nutrients and drugs, the possible role estradiol may play in modulating nutrient transport has not been established. Therefore, small intestine glucose transport was measured 1 week after administering estradiol to ovariectomized rats fed diets high in carbohydrate (C) or protein (P). Rats treated with estradiol ate 21% less (P<0.05) and lost body mass (7%; P<0.05) but did not have smaller intestines. Administration of estradiol increased rates of glucose transport, but only when the rats were fed the C diet. These findings indicate that estradiol causes a disconnect between food intake and the dimensions and nutrient transport capacities of the small intestine. Furthermore, the responses to estradiol are influenced by diet composition, are not of the same magnitude for rats and dogs, and can be predicted to affect systemic availability of nutrients and drugs. |
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Authors:
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Yasuhiro Kimura; Karyl K Buddington; Randal K Buddington |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 229 ISSN: 1535-3702 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-27 Completed Date: 2004-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: United States |
Other Details:
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Languages: eng Pagination: 227-34 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Mississippi State University, Mississippi State, Mississippi 39762, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Diet* Dietary Carbohydrates Dietary Proteins Estradiol / pharmacology* Female Glucose / metabolism* Intestinal Absorption / drug effects*, physiology Intestine, Small / drug effects Ovariectomy* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Proteins; 50-28-2/Estradiol; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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