Document Detail

The influence of endoscopic variceal ligation on the portal pressure gradient in cirrhotics.
MedLine Citation:
PMID:  12630002     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: After variceal eradication by endoscopic ligation, fundal varices and worsening of portal hypertensive gastropathy can occur. The aim of this study is to verify the impact of the eradication of esophageal varices by endoscopic ligation on the portal pressure gradient, worsening of portal hypertensive gastropathy and development of fundal varices. METHODOLOGY: Twenty-two (15M/7F, mean age: 54.5 years) cirrhotics with previous variceal bleeding were submitted to measurement of hepatic venous pressure gradient before and after variceal eradication by endoscopic ligation. RESULTS: The mean hepatic venous pressure gradient in the first measurement was 14.1 mmHg and after eradication, 13.5 mmHg (p = 0.403). After eradication, 12 patients experienced a reduction in portal pressure and 10, an elevation. Three patients developed fundal varices. Their mean gradient before treatment was 22 mmHg and 18.8 mmHg after therapy (p = 0.368). The gastropathy worsened in 9 patients (mean gradient before therapy of 15.2 mmHg; and 16.1 mmHg after treatment) (p = 0.303). The initial pressure gradient of these patients was not different from the other 13 cases (p = 0.463). CONCLUSIONS: The esophageal variceal eradication by endoscopic band ligation does not alter the hepatic venous pressure gradient. There is no significant variation in the portal pressure of patients in whom there was a worsening of portal hypertensive gastropathy or fundal varices development.
Júlio C Pereira-Lima; Marília Zanette; César Vivian Lopes; Angelo A de Mattos
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  50     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Porto Alegre School of Medical Sciences (FFFCMPA), Santa Casa University Hospital, Porto Alegre, Brazil.
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MeSH Terms
Endoscopy / adverse effects*
Esophageal and Gastric Varices / etiology*,  physiopathology,  surgery*
Gastric Fundus / physiopathology,  surgery*
Hypertension, Portal / etiology*,  physiopathology
Ligation / adverse effects
Liver Cirrhosis / physiopathology,  surgery*
Middle Aged
Portal Pressure / physiology
Postoperative Complications*
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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