Document Detail

The influence of early postnatal nutrition on retinopathy of prematurity in extremely low birth weight infants.
MedLine Citation:
PMID:  20561759     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Retinopathy of prematurity(ROP) is the most common serious ophthalmic disease in preterm infants. Human milk may provide a protective effect for ROP; however, beneficial effects of human milk preclude randomized trials. Therefore, we conducted a retrospective analysis comparing early postnatal nutrition with ROP development. OBJECTIVE: Evaluate relationship between early postnatal nutriture and ROP surgery. DESIGN/METHODS: Nutrition data was collected for inborn AGA infants, BW 700-1000 g. ROP surgery was the primary outcome variable. A single pediatric ophthalmologist supervised examinations. All infants received triweekly IM vitamin A as chronic lung disease prophylaxis (Tyson: NEJM, 1999). RESULTS: BW and gestational age were 867+/-85 g and 26.3+/-1.2 weeks (n=77, mean+/-1SD). ROP surgery infants(n=11) received more parenteral nutrition, 1648 mL, and less human milk, 13.8 mL/kg-day, and vitamin E, 1.4 mg/kg-day, during the second postnatal week. Human milk was a negative predictor for ROP surgery, odds ratio=0.94. Both groups met vitamin A recommendations; however, 74% was administered via IM injections. Neither group met vitamin E recommendations. CONCLUSIONS: Human milk feeding, parenteral nutrition volume and vitamin E intake were predictors for ROP surgery. IM vitamin A injections provided the majority of vitamin A; vitamin E administration was insufficient. Improving human milk feeding rates and vitamin dosing options may affect ROP surgery rates.
Peter J Porcelli; R Grey Weaver
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-18
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Pediatrics, Wake Forest University, Winston-Salem, NC 27157, United States.
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MeSH Terms
Infant, Newborn
Infant, Very Low Birth Weight*
Lung Diseases / prevention & control
Milk, Human*
Nutrition Assessment
Parenteral Nutrition
Retinopathy of Prematurity / prevention & control*,  surgery
Retrospective Studies
Vitamin A / therapeutic use
Vitamin E / therapeutic use
Reg. No./Substance:
11103-57-4/Vitamin A; 1406-18-4/Vitamin E

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