Document Detail

The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model.
MedLine Citation:
PMID:  10890969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model. METHODS: BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pressures of 5, 10 or 15 mmHg; full laparotomy for 60 min; or anesthesia control. Cancer nodules on the lung surface 19 days postoperatively were compared between groups. RESULTS: (a) As compared with the control group, pneumoperitoneum at 10 and 15 mmHg and laparotomy enhanced the growth of pulmonary metastases (p < 0.01). (b) The growth of metastases also was greater in laparotomy group mice than in mice undergoing pneumoperitoneum at 5 and 10 mmHg (p < 0.05). CONCLUSIONS: These results suggest that the effects of different insufflation pressures on the growth of pulmonary metastases are not identical, and that pneumoperitoneum with high pressure may promote pulmonary metastases similar to those with laparotomy.
H Ishida; N Murata; M Yokoyama; N Ishizuka; I Takeuchi; A Odaka; K Shimomura; M Fujioka; Y Idezuki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical endoscopy     Volume:  14     ISSN:  0930-2794     ISO Abbreviation:  Surg Endosc     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-01     Completed Date:  2000-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  578-81     Citation Subset:  IM    
Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan.
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MeSH Terms
Analysis of Variance
Carbon Dioxide
Colorectal Neoplasms / pathology*,  surgery*
Disease Models, Animal
Laparoscopy / adverse effects*,  methods
Laparotomy / adverse effects
Lung Neoplasms / etiology*,  secondary*
Mice, Inbred BALB C
Neoplasm Invasiveness
Neoplasm Transplantation
Pneumoperitoneum, Artificial / adverse effects*
Random Allocation
Reference Values
Risk Assessment
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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