Document Detail

The influence of dexamethasone on the regrowth of surgically removed fat.
MedLine Citation:
PMID:  3273086     Owner:  NLM     Status:  MEDLINE    
We investigated the interaction between long-term dexamethasone administration and lipectomy on regional fat deposits in the rat. Seven-week-old Sprague-Dawley rats (N = 24) were divided into 3 test groups. Group 1 (control) received 0.5 ml/kg of saline intramuscularly daily; group 2, 1 microgram dexamethasone intramuscularly; group 3, 5 micrograms dexamethasone intramuscularly. At week 9 a lipectomy of 4 regional fat deposits on the right side of the animal was done: inguinal, epididymal, interscapular, and perirenal. Injections continued for an additional 27 weeks, at which time a lipectomy was done removing left-sided depots in addition to any "regrown fat" on the previously dissected right side. Several conclusions can be made. First, rats receiving 5 micrograms/kg reaccumulated more fat than the controls in the inguinal, perirenal, and interscapular depots. Second, fat cell size in this model greatly influenced the ultimate size of each depot. Third, fat depots vary in their response to steroids and lipectomy because of local and systemic factors.
M F Angel; S S Ramasastry; W M Swartz; V DeRiso; J W Futrell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  17     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1990-04-17     Completed Date:  1990-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
Division of Plastic and Reconstructive Surgery, University of Pittsburgh, School of Medicine, PA.
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MeSH Terms
Adipose Tissue / drug effects*,  growth & development,  surgery
Dexamethasone / pharmacology*
Dose-Response Relationship, Drug
Rats, Inbred Strains
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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