Document Detail

The influence of deleterious mutations on adaptation in asexual populations.
MedLine Citation:
PMID:  22110756     Owner:  NLM     Status:  MEDLINE    
We study the dynamics of adaptation in asexual populations that undergo both beneficial and deleterious mutations. In particular, how the deleterious mutations affect the fixation of beneficial mutations was investigated. Using extensive Monte Carlo simulations, we find that in the "strong-selection weak mutation (SSWM)" regime or in the "clonal interference (CI)" regime, deleterious mutations rarely influence the distribution of "selection coefficients of the fixed mutations (SCFM)"; while in the "multiple mutations" regime, the accumulation of deleterious mutations would lead to a decrease in fitness significantly. We conclude that the effects of deleterious mutations on adaptation depend largely on the supply of beneficial mutations. And interestingly, the lowest adaptation rate occurs for a moderate value of selection coefficient of deleterious mutations.
Xiaoqian Jiang; Zhao Xu; Jingjing Li; Youyi Shi; Wenwu Wu; Shiheng Tao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-14
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-23     Completed Date:  2012-03-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e27757     Citation Subset:  IM    
Bioinformatics Center, College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
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MeSH Terms
Adaptation, Physiological / genetics*
Evolution, Molecular
Models, Biological*
Monte Carlo Method
Reproduction, Asexual / genetics*
Selection, Genetic

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