Document Detail


The influence of dehydroepiandrosterone on early pregnancy in mice.
MedLine Citation:
PMID:  16166807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice. Pregnant animals were injected with DHEA following both the post-implantatory (DHEA-2) and peri-implantatory (DHEA-6) models. Morphological studies of implantation sites showed 40% of embryonic resorption in the DHEA-2 group while 100% of resorption was observed in the DHEA-6 group. Serum samples of both DHEA-2 and DHEA-6 groups showed higher estradiol levels and a lower progesterone concentration than those of control groups. Ovarian prostaglandin E levels after both DHEA-2 and DHEA-6 treatments increased when compared to control groups. The antioxidant metabolite glutathione diminished during both DHEA treatments. In summary, the data presented here suggest that DHEA treatment during early pregnancy modulates the ovarian function and is responsible for embryonic resorption with different degrees depending on when it is administered.
Authors:
Valeria Sander; María Emilia Solano; Evelin Elia; Carolina Griselda Luchetti; Guillermo Di Girolamo; Claudio Gonzalez; Alicia B Motta
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroimmunomodulation     Volume:  12     ISSN:  1021-7401     ISO Abbreviation:  Neuroimmunomodulation     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-16     Completed Date:  2005-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9422763     Medline TA:  Neuroimmunomodulation     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Affiliation:
Centro de Estudios Farmacológicos y Botánicos, Consejo de Investigaciones Científicas y Tecnológicas, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology*
Animals
Dehydroepiandrosterone / pharmacology*
Embryo Implantation / physiology
Embryo Loss / chemically induced
Embryo, Mammalian
Embryonic Development
Estradiol / blood
Female
Glutathione / analysis,  drug effects*
Mice
Mice, Inbred BALB C
Ovary / drug effects
Pregnancy
Progesterone / blood
Time Factors
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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