Document Detail

The influence of dehydroepiandrosterone on early pregnancy in mice.
MedLine Citation:
PMID:  16166807     Owner:  NLM     Status:  MEDLINE    
The aim of the present report was to study the role of high levels of dehydroepiandrosterone (DHEA) on the ovarian function and embryonic resorption during early pregnancy in BALB/c mice. Pregnant animals were injected with DHEA following both the post-implantatory (DHEA-2) and peri-implantatory (DHEA-6) models. Morphological studies of implantation sites showed 40% of embryonic resorption in the DHEA-2 group while 100% of resorption was observed in the DHEA-6 group. Serum samples of both DHEA-2 and DHEA-6 groups showed higher estradiol levels and a lower progesterone concentration than those of control groups. Ovarian prostaglandin E levels after both DHEA-2 and DHEA-6 treatments increased when compared to control groups. The antioxidant metabolite glutathione diminished during both DHEA treatments. In summary, the data presented here suggest that DHEA treatment during early pregnancy modulates the ovarian function and is responsible for embryonic resorption with different degrees depending on when it is administered.
Valeria Sander; María Emilia Solano; Evelin Elia; Carolina Griselda Luchetti; Guillermo Di Girolamo; Claudio Gonzalez; Alicia B Motta
Related Documents :
11753527 - Early pregnancy is elusive and robust.
18581767 - Laparoscopic treatment of ovarian dermoid cysts.
17308927 - How to reduce diathermy in tonsillectomy: description of technique and analysis of resu...
24858317 - Twin anemia-polycythemia sequence in monochorionic twins: implications for diagnosis an...
6253637 - Enhanced excitability of the uterus of the pregnant rabbit by imidazole stimulation of ...
16084867 - Failure of the emergency contraceptive levonorgestrel and the risk of adverse effects i...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroimmunomodulation     Volume:  12     ISSN:  1021-7401     ISO Abbreviation:  Neuroimmunomodulation     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-16     Completed Date:  2005-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9422763     Medline TA:  Neuroimmunomodulation     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  285-92     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Centro de Estudios Farmacológicos y Botánicos, Consejo de Investigaciones Científicas y Tecnológicas, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adjuvants, Immunologic / pharmacology*
Dehydroepiandrosterone / pharmacology*
Embryo Implantation / physiology
Embryo Loss / chemically induced
Embryo, Mammalian
Embryonic Development
Estradiol / blood
Glutathione / analysis,  drug effects*
Mice, Inbred BALB C
Ovary / drug effects
Progesterone / blood
Time Factors
Reg. No./Substance:
0/Adjuvants, Immunologic; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hypothalamic proline-rich polypeptide is a regulator of oxidative burst in human neutrophils and mon...
Next Document:  Efavirenz induces depressive-like behaviour, increased stress response and changes in the immune res...