Document Detail


The influence of daytime inactivity and nighttime restlessness on cancer-related fatigue.
MedLine Citation:
PMID:  10573683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE/OBJECTIVES: To identify indicators involving circadian activity/rest cycles associated with higher levels of cancer-related fatigue (CRF) during the first three chemotherapy cycles after surgery for stage I/II breast cancer. DESIGN: Prospective, descriptive, repeated measures. SETTING: Midwestern oncology clinics and subjects' homes. SAMPLE: 72 women, ages 33-69 and free of unstable chronic illnesses, entered the study. Complete data were obtained from 30-47 subjects at each time. METHODS: CRF was measured using the Piper Fatigue Scale at the start and midpoint of each chemotherapy cycle. Circadian activity/rest indicators were obtained using Mini-Motionlogger wrist actigraphs for 96 hours at the start of each treatment and for 72 hours at the midpoint of each chemotherapy cycle. MAIN RESEARCH VARIABLES: Fatigue and circadian activity/rest indicators. FINDINGS: Women who were less active and had increased night awakenings reported higher CRF levels at all three cycle midpoints, with the strongest association being number of night awakenings. During the third chemotherapy cycle, women who were less active during the day, took more naps, and spent more time resting during a 24-hour period experienced higher CRF. CONCLUSIONS: Women whose sleep is disrupted at cycle midpoints are at risk for CRF. The cumulative effects of less daytime activity, more daytime sleep, and night awakenings are associated with higher CRF levels. IMPLICATIONS FOR NURSING PRACTICE: Assessment of CRF and night awakenings at the midpoints of each chemotherapy cycle and development of nursing interventions to promote daytime activity and nighttime rest are key to managing fatigue and preventing loss of biologic rhythmicity.
Authors:
A M Berger; L Farr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology nursing forum     Volume:  26     ISSN:  0190-535X     ISO Abbreviation:  Oncol Nurs Forum     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7809033     Medline TA:  Oncol Nurs Forum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1663-71     Citation Subset:  IM; N    
Affiliation:
College of Nursing, University of Nebraska Medical Center, Omaha, USA. aberger@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Activity Cycles*
Adult
Aged
Analysis of Variance
Antineoplastic Agents / adverse effects*
Breast Neoplasms / drug therapy,  physiopathology*
Fatigue / etiology,  physiopathology*
Female
Humans
Middle Aged
Prospective Studies
Regression Analysis
Sleep Initiation and Maintenance Disorders / etiology,  physiopathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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