Document Detail

The influence of cyclo-oxygenase inhibitors on the cardiovascular effects of hydralazine in rats.
MedLine Citation:
PMID:  3923959     Owner:  NLM     Status:  MEDLINE    
In order to explore the postulated role of prostaglandins in the vasodilator effects of hydralazine, blood pressure and heart rate responses to the drug were determined in anesthetized and conscious rats with and without pretreatment with indomethacin or aspirin. Changes in rectal temperature were also measured. In control animals, hydralazine produced an almost immediate fall in blood pressure and a slowly developing tachycardia which bore no temporal relation with the hypotension. These effects were accompanied by a moderate increase in temperature. Pretreatment with the cyclo-oxygenase inhibitors did not reduce the blood pressure response, but completely blocked and in some cases reversed the tachycardia. The hyperthermic response was also reversed. These results can be taken as evidence for a role of prostaglandins in the tachycardia and hyperthermia, but not in the hypotension elicited by hydralazine in rats. In the absence of direct measurements of prostaglandin synthesis and release, however, no firm support for this possibility is offered by the present findings and alternative explanations are considered.
H Vidrio; F Garcia-Marquez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  273     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  IM    
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MeSH Terms
Aspirin / pharmacology
Blood Pressure / drug effects
Body Temperature / drug effects
Cyclooxygenase Inhibitors*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hydralazine / pharmacology*
Indomethacin / pharmacology
Prostaglandins / physiology
Rats, Inbred Strains
Vasodilation / drug effects
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 50-78-2/Aspirin; 53-86-1/Indomethacin; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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