Document Detail


The influence of cutting the pancreatic nerve plexus on exocrine function in the pancreas of rats.
MedLine Citation:
PMID:  2478411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to clarify changes in protein synthesis and exocrine enzymes of the pancreas after cutting the pancreatic nerve plexus of Wistar rats. The rats were divided into two groups, consisting of a group that underwent cutting of the pancreatic nerve plexus (neurotomy group) and a group that underwent a sham operation (control group). 3H-leucine uptake in the pancreatic protein fraction of the neurotomy group at 3, 5 and 7 days after the operation was significantly lower than that of the control group (P less than 0.05-0.01), and this low uptake returned to the normal range at 14 days. Amylase, lipase and trypsin values in pancreatic tissue of the neurotomy group decreased during the period of from 1 to 7 days, and there were significant differences in the values of the respective enzymes at 5 or 7 days between the neurotomy and the control group (P less than 0.05). Thereafter, all enzyme values increased to within the normal range. Upon examination of pancreatic blood flow using a microsphere, the neurotomy group showed a significant reduction at 7 days compared with the control group (P less than 0.05), and thereafter exhibited recovery of blood flow. These results indicate that after cutting the pancreatic nerve plexus, exocrine function in the pancreas is reduced immediately but recovers within a short period of time, and that these changes in exocrine function are affected by blood flow in the pancreas.
Authors:
Y Kinami; H Sakuma
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  24     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-04     Completed Date:  1989-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  549-55     Citation Subset:  IM    
Affiliation:
Second Department of Surgery, Kanazawa Medical University, Ishikawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amylases / metabolism
Animals
Autonomic Nervous System / enzymology
Denervation
Duodenum / blood supply
Leucine / metabolism
Male
Nervous System Physiological Phenomena*
Pancreas / blood supply,  innervation*,  physiology
Rats
Rats, Inbred Strains
Regional Blood Flow
Trypsin / metabolism
Chemical
Reg. No./Substance:
61-90-5/Leucine; EC 3.2.1.-/Amylases; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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