Document Detail

The influence of curcumin on the action of etoposide in a rat acute myeloid leukemia cell line.
MedLine Citation:
PMID:  24858458     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: There are contradictory results from studies on the effect of curcumin, a plant phenolic compound with a well-established anticancer effect in vitro, on the action of etoposide in cancer cells.
OBJECTIVE: The aim of this study was to evaluate the influence of curcumin on the genotoxic and cytostatic action of etoposide in the LT12 cell line derived from BN rat acute myeloid leukemia cells.
MATERIAL & METHODS: The LT12 cells were treated with different doses of curcumin for 1-72 hours followed by application of etoposide. The amount of DNA damage was estimated via a comet assay. Viability, cell cycle and apoptosis were examined by using flow cytometry technique.
RESULTS: The combined effect of curcumin and etoposide on viability was synergistic at low micro- molar concentrations. In comparison to treatment with curcumin and etoposide alone, co-treatment with these compounds increased the extent of DNA damage, the percentage of cells arrested in the G2/M phase and the number of annexin-V-positive cells.
CONCLUSIONS: The interaction between etoposide and curcumin points to an enhanced antileukemic potential to be derived from the combination of these compounds.
Monika A Papiez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia medica Cracoviensia     Volume:  53     ISSN:  0015-5616     ISO Abbreviation:  Folia Med Cracov     Publication Date:  2013  
Date Detail:
Created Date:  2014-05-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374617     Medline TA:  Folia Med Cracov     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  61-72     Citation Subset:  IM    
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