Document Detail

The influence of cryopreservation on changes in diameter and compliance of allografts in an animal experimental model.
MedLine Citation:
PMID:  16564709     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to analyze the influence of cryopreservation on changes in diameter and compliance of allografts. METHODS: Sixty aortic allografts implanted in situ in rats were analyzed. The animals were divided into four groups that received fresh or cryopreserved isogenic (Lewis to Lewis) grafts, or fresh or cryopreserved allogenic (Lewis to DA) grafts, respectively. The diameter and compliance of the grafts were then visually evaluated with the digital video camera recorder after 15, 30, 60, 90 and 120 days. RESULTS: Gradual increase in diameter and decrease in compliance in case of all allogenic and cryopreserved isogenic grafts were observed. The observed changes in cryopreserved grafts were smaller when compared with fresh grafts, however, the differences did not reach statistical significance. CONCLUSION: Cryo preservation does not protect allografts from stiffening and dilatation.
M Gabriel; K Wachal; L Dzieciuchowicz; K Pawlaczyk; Z Krasiński; G Oszkinis
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Publication Detail:
Type:  Journal Article     Date:  2006-03-29
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  32     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
Department of Vascular Surgery, University of Medical Science, Poznan, Poland.
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MeSH Terms
Aorta, Abdominal / metabolism,  pathology*,  transplantation
Cell Nucleus / metabolism
Cell Proliferation
Fibroblasts / metabolism
Macrophages / metabolism
Models, Animal
Myocytes, Smooth Muscle / metabolism
T-Lymphocytes / metabolism
Transplantation, Homologous
Tunica Intima / metabolism,  pathology
Tunica Media / metabolism,  pathology

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