Document Detail


The influence of creatinine, lecithin and choline feeding on aliphatic amine production and excretion in the rat.
MedLine Citation:
PMID:  4063314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The excretion of aliphatic amines, methylamine, dimethylamine and trimethylamine in the urine and faeces of rats fed on a control diet and diets supplemented with creatinine, lecithin or choline were measured over a 14 d feeding period. The rats were then killed and concentrations of amines in small and large intestinal contents measured. Adding creatinine to the diet resulted in a significant increase of methylamine excretion in the faeces and urine. The amount of methylamine found in all parts of the intestine increased, especially in the caecum. Adding lecithin to the diet resulted in an increase in the methylamine excretion only, and no change in the concentrations of amines found in the intestine, except for trimethylamine which was significantly increased in the caecum and colon. Adding choline to the diet resulted in a significant increase in excretion of trimethylamine and, to a lesser extent, methylamine. The levels of amines found in the gut increased, dimethylamine being increased in the small bowel, and methylamine and trimethylamine in the caecum.
Authors:
S Lowis; M A Eastwood; W G Brydon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  54     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-12-27     Completed Date:  1985-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Choline / administration & dosage*,  pharmacology
Creatinine / administration & dosage*,  pharmacology
Diet*
Dimethylamines / biosynthesis*,  urine
Male
Methylamines / biosynthesis*,  urine
Phosphatidylcholines / administration & dosage*,  pharmacology
Rats
Chemical
Reg. No./Substance:
0/Dimethylamines; 0/Methylamines; 0/Phosphatidylcholines; 124-40-3/dimethylamine; 60-27-5/Creatinine; 62-49-7/Choline; 74-89-5/methylamine; 75-50-3/trimethylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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