Document Detail


The influence of copper concentration and source on ileal microbiota.
MedLine Citation:
PMID:  19211529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Copper is normally supplemented in poultry diets as a growth promotant and antimicrobial. However, there are conflicting reports about the growth benefits and little information about how Cu affects the microbiota in the intestinal tract of poultry. Therefore, in vitro and in vivo experiments were conducted with broilers to determine the effects of Cu source and supplementation on ileal microbiota. The influence of Cu on growth of lactobacilli and Escherichia coli in media inoculated with ileal contents was determined in the first study. When Cu sulfate pentahydrate was supplemented to the cultures, quadratic increases in lactobacilli to graded concentrations of Cu up to 125 mg/kg and quadratic decreases in E. coli up to 250 mg/kg of Cu were observed after 24 h of incubation at 37 degrees C. However, when tribasic Cu chloride (TBCC) was supplemented, neither linear nor quadratic responses to graded concentrations of dietary Cu were observed on number of lactobacilli or number of E. coli. The effects of Cu and Cu source on ileal microbiota and growth performance in broiler chickens were determined in the second study. Bird performance was not affected by Cu source or concentration. The bacterial culture enumeration results revealed that supplementation with 187.5 mg/kg of Cu from Cu sulfate pentahydrate and TBCC had no effect on number of ileal lactobacilli of birds. The denaturing gradient gel electrophoresis analyses of ileal microbial communities revealed that neither Cu supplementation nor source had effects on the number of bacterial species predominant in the ileal digesta or associated with the ileal mucosa. Supplementation with TBCC supplementation significantly increased the similarity coefficients of microbiota in the ileal mucosa compared with cross-products of all individuals. This suggests that TBCC may alter the intestinal microbiota, yet this shift had no effect on bird performance.
Authors:
Y Pang; J A Patterson; T J Applegate
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  88     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-92     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907-2054, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed / analysis*
Animal Nutritional Physiological Phenomena
Animals
Chickens / physiology*
Copper / administration & dosage*,  pharmacology*
Diet / veterinary*
Dose-Response Relationship, Drug
Ileum / microbiology*
Lactobacillus / drug effects
Male
Chemical
Reg. No./Substance:
7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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