| The influence of contrast agent injection on physiological flow in the circle of Willis. | |
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MedLine Citation:
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PMID: 20980191 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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X-ray videodensitometry allows in vivo flow measurements from gradients in contrast agent concentration. However, the injection of contrast agent alters the flow to be measured. Here, the temporal, spatial, and inter-patient variability of the response to injection are examined. To this purpose, an injection is prescribed in the internal carotid in a 1D wave propagation model of the arterial circulation. Although the resulting effect of injection is constant over a cardiac cycle, the response does vary with the location within the cerebral circulation and the geometry of the circle of Willis. At the injection site, the injection partly suppresses the incoming blood flow, such that the distal flow is increased by approximately 10%. This corresponds to approximately 20% of the injection rate added to the blood flow during injection, depending on the vascular geometry. In the communicating arteries, the flow direction is reversed during injection. Since the measured flow is not equal to the physiological blood flow, the effect of injection should be taken into account when deriving the flow from travelling contrast agent. |
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Authors:
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G Mulder; A C B Bogaerds; P Rongen; F N van de Vosse |
Publication Detail:
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Type: Journal Article Date: 2010-10-25 |
Journal Detail:
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Title: Medical engineering & physics Volume: 33 ISSN: 1873-4030 ISO Abbreviation: Med Eng Phys Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422753 Medline TA: Med Eng Phys Country: England |
Other Details:
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Languages: eng Pagination: 195-203 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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