Document Detail


The influence of the compounding process and testing conditions on the compressive mechanical properties of poly(D,L-lactide-co-glycolide)/α-tricalcium phosphate nanocomposites.
MedLine Citation:
PMID:  21783117     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The enhanced biological and degradation properties of bioresorbable polymer matrix nanocomposites intended for use in orthopaedic applications have been demonstrated recently. However, at the moment there are only limited reports addressing their mechanical properties under physiological conditions, which is of central importance to the successful design of these nanocomposites. Here, we show that at room temperature in dry conditions, the incorporation of α-tricalcium phosphate nanoparticles into a matrix of poly(D,L-lactide-co-glycolide) increases the compressive strength and modulus. The values at room temperature obtained for nanocomposites compounded by a modified solvent evaporation method via attrition milling in acetone were similar to those from samples compounded by twin screw extrusion. The values for nanocomposites tested at 37 °C in phosphate buffered saline solution were significantly lower than those tested at room temperature in dry conditions, and lower still after two weeks of degradation in PBS at 37 °C. These effects can be related to hydration, degradation and interface effects in the nanocomposites.
Authors:
Samuel I J Wilberforce; Chris E Finlayson; Serena M Best; Ruth E Cameron
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Publication Detail:
Type:  Journal Article     Date:  2011-03-23
Journal Detail:
Title:  Journal of the mechanical behavior of biomedical materials     Volume:  4     ISSN:  1878-0180     ISO Abbreviation:  J Mech Behav Biomed Mater     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101322406     Medline TA:  J Mech Behav Biomed Mater     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1081-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3QZ, UK.
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