Document Detail

The influence of combined oral contraceptives on female sexual desire: A systematic review.
MedLine Citation:
PMID:  23320933     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT Objectives To determine the relationship between the use of combined oral contraceptives (COCs) and sexual desire based on a systematic review of the literature. Methods MEDLINE Complete, Google Scholar and the Cochrane Library were searched for articles published between 1975 and 2011, reporting the effects of oral contraceptives on sexual desire. Reports fully meeting all the predefined criteria were analysed and included in a final reference list. In addition, a review of the reference list of selected articles was carried out. Results We evaluated 36 studies (1978-2011; 13,673 women). Of the COC users (n = 8,422), 85% reported an increase (n = 1,826) or no change (n = 5,358) in libido and 15% reported a decrease (n = 1,238). We found no significant difference in sexual desire in the case of COCs with 20-35 μg ethinylestradiol; libido decreased only with pills containing 15 μg ethinylestradiol. Conclusions The majority of COC users report no significant change in libido although in most studies a decline in plasma levels of free testosterone and an increase in those of sex hormone binding globulin were observed.
Zlatko Pastor; Katerina Holla; Roman Chmel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception     Volume:  18     ISSN:  1473-0782     ISO Abbreviation:  Eur J Contracept Reprod Health Care     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712127     Medline TA:  Eur J Contracept Reprod Health Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-43     Citation Subset:  IM    
* Obstetrics and Gynaecology Department , 2nd Medical Faculty, Teaching Hospital Motol, Charles University, Prague , Czech Republic.
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