Document Detail


The influence of chronic hypoxia upon chemoreception.
MedLine Citation:
PMID:  17291837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carotid body chemoreceptors are essential for time-dependent changes in ventilatory control during chronic hypoxia. Early theories of ventilatory acclimatization to hypoxia focused on time-dependent changes in known ventilatory stimuli, such as small changes in arterial pH that may play a significant role in some species. However, plasticity in the cellular and molecular mechanisms of carotid body chemoreception play a major role in ventilatory acclimatization to hypoxia in all species studied. Chronic hypoxia causes changes in (a) ion channels (potassium, sodium, calcium) to increase glomus cell excitability, and (b) neurotransmitters (dopamine, acetylcholine, ATP) and neuromodulators (endothelin-1) to increase carotid body afferent activity for a given PO(2) and optimize O(2)-sensitivity. O(2)-sensing heme-containing molecules in the carotid body have not been studied in chronic hypoxia. Plasticity in medullary respiratory centers processing carotid body afferent input also contributes to ventilatory acclimatization to hypoxia. It is not known if the same mechanisms occur in patients with chronic hypoxemia from lung disease or high altitude natives.
Authors:
Frank L Powell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-01-20
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  157     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-07-12     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Affiliation:
Department of Medicine and White Mountain Research Station, University of California, San Diego, La Jolla, CA 92093-0623, USA. fpowell@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology*
Animals
Anoxia / metabolism*,  physiopathology
Atmospheric Pressure
Carotid Body / physiology*
Chemoreceptor Cells / metabolism*
Humans
Mechanotransduction, Cellular / physiology*
Neuronal Plasticity / physiology*
Neurotransmitter Agents / metabolism
Pulmonary Ventilation / physiology
Grant Support
ID/Acronym/Agency:
HL81823/HL/NHLBI NIH HHS; R01 HL081823/HL/NHLBI NIH HHS; R01 HL081823-01/HL/NHLBI NIH HHS; R01 HL081823-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents
Comments/Corrections

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