| The influence of chronic hypoxia upon chemoreception. | |
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MedLine Citation:
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PMID: 17291837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid body chemoreceptors are essential for time-dependent changes in ventilatory control during chronic hypoxia. Early theories of ventilatory acclimatization to hypoxia focused on time-dependent changes in known ventilatory stimuli, such as small changes in arterial pH that may play a significant role in some species. However, plasticity in the cellular and molecular mechanisms of carotid body chemoreception play a major role in ventilatory acclimatization to hypoxia in all species studied. Chronic hypoxia causes changes in (a) ion channels (potassium, sodium, calcium) to increase glomus cell excitability, and (b) neurotransmitters (dopamine, acetylcholine, ATP) and neuromodulators (endothelin-1) to increase carotid body afferent activity for a given PO(2) and optimize O(2)-sensitivity. O(2)-sensing heme-containing molecules in the carotid body have not been studied in chronic hypoxia. Plasticity in medullary respiratory centers processing carotid body afferent input also contributes to ventilatory acclimatization to hypoxia. It is not known if the same mechanisms occur in patients with chronic hypoxemia from lung disease or high altitude natives. |
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Authors:
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Frank L Powell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2007-01-20 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 157 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-04-27 Completed Date: 2007-07-12 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 154-61 Citation Subset: IM |
Affiliation:
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Department of Medicine and White Mountain Research Station, University of California, San Diego, La Jolla, CA 92093-0623, USA. fpowell@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology* Animals Anoxia / metabolism*, physiopathology Atmospheric Pressure Carotid Body / physiology* Chemoreceptor Cells / metabolism* Humans Mechanotransduction, Cellular / physiology* Neuronal Plasticity / physiology* Neurotransmitter Agents / metabolism Pulmonary Ventilation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL81823/HL/NHLBI NIH HHS; R01 HL081823/HL/NHLBI NIH HHS; R01 HL081823-01/HL/NHLBI NIH HHS; R01 HL081823-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
| Comments/Corrections | |
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