Document Detail

The influence of changes in the size of ischemic region on ST-segment potential distribution in isolated canine hearts.
MedLine Citation:
PMID:  3723777     Owner:  NLM     Status:  MEDLINE    
In order to investigate how a change in the size of a ischemic region is reflected in ST-segment mapping studies, we produced two different sizes of ischemic regions by occluding proximal or distal portions of the left circumflex artery for five minutes, using ten isolated canine heart preparations. We examined the relationship between the geometry of the ischemic region and ST-segment potential distribution on the epicardial surface and that in the "precordium", in which the heart was suspended. The extent of the ischemic region was reflected differently on epicardial and "precordial" sites, in that the magnitude of epicardial ST-segment elevation decreased (p less than 0.001) while the "precordial" one increased (p less than 0.01). In the epicardium the degree of ST-segment elevation was almost uniform over the ischemic region, whereas in the "precordium" it was maximal at sites overlying the center of the ischemic region and progressively decreased approaching the periphery. However, frequent occurrence of intraventricular conduction disturbance was observed near the center of the ischemic region. As a result, the magnitude of epicardial ST-segment elevation near the center became larger than in the periphery. These results suggest that the classical solid angle theory provides a useful approximation of the ST-segment deflection in very acute ischemic phase, until development of the intraventricular conduction delay.
H Kyono; K Maehara; Y Maruyama; Y Shimizu; S Kitaoka; Y Ishiki; S Yoshikata; E Ino-Oka; T Takishima
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  50     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-08-06     Completed Date:  1986-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  147-60     Citation Subset:  IM    
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MeSH Terms
Heart Conduction System / physiology*
Myocardial Infarction / pathology,  physiopathology*
Myocardium / pathology
Organ Size
Pericardium / physiology

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