Document Detail

The influence of cell volume changes on tumour cell proliferation.
MedLine Citation:
PMID:  14598000     Owner:  NLM     Status:  MEDLINE    
Ion channels and cell volume control participate in a wide variety of cellular functions, including cell proliferation. According to the "pump-leak model" or the "double Donnan system", the cell volume is constant in physiological medium so long as the cell metabolism and the Na-K pump are not inhibited and the passive Na+ permeability is not dramatically increased. At short term, this model has been supported by a large number of experiments made on different cell types. However, at long term, it may be insufficient to describe the volume control because it does not take into account the fact that cells possess a large number of membrane transporters and interconnected volume regulatory mechanisms. In this review, we present recent results indicating that, in physiological conditions, ion channels may have important roles in cell volume control. Furthermore, we emphasize that cell proliferation and volume are phenomenologically correlated. On the basis of the macromolecular crowding theory, the possibility that the cell osmolyte and water content mediates this correlation is discussed.
Jean-Marc Dubois; Béatrice Rouzaire-Dubois
Publication Detail:
Type:  Journal Article; Review     Date:  2003-11-04
Journal Detail:
Title:  European biophysics journal : EBJ     Volume:  33     ISSN:  0175-7571     ISO Abbreviation:  Eur. Biophys. J.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-08-09     Completed Date:  2005-03-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8409413     Medline TA:  Eur Biophys J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, 91198 Gif-sur-Yvette Cedex, France.
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MeSH Terms
Cell Division / physiology*
Cell Membrane / metabolism
Cell Size*
Ion Channel Gating / physiology
Ion Channels / physiology*
Membrane Transport Proteins / metabolism
Sodium-Potassium-Exchanging ATPase / metabolism
Tumor Cells, Cultured
Water-Electrolyte Balance
Reg. No./Substance:
0/Ion Channels; 0/Membrane Transport Proteins; EC ATPase

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