Document Detail

The influence of cell co-operation, nutrients and surface area on cell division.
MedLine Citation:
PMID:  8439588     Owner:  NLM     Status:  MEDLINE    
Two opposite views have been proposed to explain the decline of the growth potential in cell populations with a limited life span: 1 variations in the probability of cycling and in cycling times or 2 a progressive increase in the nondividing cell fraction. Human brain-derived cells were studied with respect to their proliferative potential under the influence of different growth conditions, using haptotactic palladium islands on agarose. The results emphasize the need for cell co-operation, surface area and nutrients for cell division. These parameters also influence the final cell density. The results illustrate the multiple factors that can vary the probability of initiating the division cycle and stress the uncertainty of defining the irreversible non-dividing state.
E Blomquist; U Brunk; A Macieira-Coelho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell proliferation     Volume:  26     ISSN:  0960-7722     ISO Abbreviation:  Cell Prolif.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-31     Completed Date:  1993-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105195     Medline TA:  Cell Prolif     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Department of Oncology, Uppsala University, Sweden.
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MeSH Terms
Cell Communication*
Cell Count* / drug effects
Cell Division* / drug effects
Cell Line / drug effects
Culture Media / pharmacology*
Ferric Compounds / pharmacology
Reg. No./Substance:
0/Culture Media; 0/Ferric Compounds; 7440-05-3/Palladium

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